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The structures of premithramycinone and demethylpremithramycinone, plausible early intermediates of the aureolic acid group antibiotic mithramycin

Jürgen Rohr, Ulrike Weißbach, Claus Beninga, Eva Künzel, Jürgen Rohr, Karsten Siems, Kai U. Bindseil, Felipe Lombó, Laura Prado, Alfredo F. Braña,

Chemical Communications · 1998 · 25 citations · 10 references

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Abstract

The structures of premithramycinone and its demethyl analogue suggest that the aureolic acid antibiotics are biosynthetically formed via a tetracycline-type, and not a tetracenomycin-type, folded decaketide.

References

10

Solution structure of the mithramycin dimer-DNA complex

Mallika Sastry, Dinshaw J. Patel · Biochemistry · 1993 · 143 citations

, , +12

Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin

Felipe Lombó, Gloria Blanco, Ernestina Fernández et al. · Gene · 1996 · 100 citations

, , +13

Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin

Felipe Lombó, Karsten Siems, Alfredo F. Braña et al. · Journal of Bacteriology · 1997 · 74 citations

, , +17

The Streptomyces glaucescens tcmKL polyketide synthase and tcmN polyketide cyclase genes govern the size and shape of aromatic polyketides

Ben Shen, R G Summers, Evelyn Wendt-Pienkowski et al. · Journal of the American Chemical Society · 1995 · 68 citations

, , +8

Rational Design and Engineered Biosynthesis of a Novel 18-Carbon Aromatic Polyketide

Peter Krämer, Robert J.X. Zawada, Robert McDaniel et al. · Journal of the American Chemical Society · 1997 · 55 citations

, , +17