The structures of premithramycinone and demethylpremithramycinone, plausible early intermediates of the aureolic acid group antibiotic mithramycin

Abstract

The structures of premithramycinone and its demethyl analogue suggest that the aureolic acid antibiotics are biosynthetically formed via a tetracycline-type, and not a tetracenomycin-type, folded decaketide.