Procathepsin D Interacts with Prosaposin in Cancer Cells but Its Internalization Is Not Mediated by LDL Receptor-Related Protein

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

Joachim Herz, J L Goldstein, Dudley K. Strickland et al. · Journal of Biological Chemistry · 1991 · 584 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

Paul Säftig, Michal Hetman, Wolfgang W. Schmahl et al. · The EMBO Journal · 1995 · 442 citations · Full text

Medicine, Pathobiology, Pathology +17

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

FRANCHISE VIGNON, FRANQOISE CAPONY, MONIQUE GHAMBON et al. · Endocrinology · 1986 · 273 citations

Life Sciences, Biochemistry, Endocrinology +13

Cathepsin D is membrane-associated in macrophage endosomes.

S Diment, Melinda S Leech, Philip D. Stahl · Journal of Biological Chemistry · 1988 · 259 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients

John A. Foekens, Maxime P. Look, Joan Bolt‐de Vries et al. · British Journal of Cancer · 1998 · 204 citations · Full text

Medicine, Cancer Biology, Oncology +16