Concepedia

Synthesis of Functionalized Cyanopyrazoles via Magnesium Bases

Allan Dishington, J. Lyman Feron, Kathryn Gill, M. A. Graham, Ian Hollingsworth, Jennifer H. Pink, Andrew Roberts, Iain Simpson, Matthew R. Tatton

Organic Letters · 2014 · 18 citations · 5 references

DOI

Concepts

Abstract

4-Alkyl- and 4-H-pyrazoles were sequentially metalated using TMPMgCl·LiCl, and their reaction with electrophiles afforded 3-aryl-4-alkyl-5-cyanopyrazoles.

References

5

<i>Nine Times Fluoride can be Good for your Syntheses.</i> Not just Cheaper: Nonafluorobutanesulfonates as Intermediates for Transition Metal‐Catalyzed Reactions

Jens Högermeier, Hans‐Ulrich Reißig · Advanced Synthesis & Catalysis · 2009 · 135 citations

, , +9

Highly Regioselective Synthesis of 1-Aryl-3,4,5-Substituted Pyrazoles

Francis Gosselin, Paul O’Shea, Robert G. Webster et al. · Synlett · 2006 · 114 citations

, , +9

Synthesis of Fully Substituted Pyrazoles via Regio- and Chemoselective Metalations

Christina Despotopoulou, Lydia Klier, Paul Knochel · Organic Letters · 2009 · 92 citations

, , +7

Pd-catalyzed Negishi coupling of pyrazole triflates with alkyl zinc halides

Ting Zhang, Xiaodi Gao, Harold B. Wood · Tetrahedron Letters · 2010 · 25 citations

, , +11

Sodium Bis(trimethylsilyl)amide in the "One-Flask" Transformation of Aromatic Esters to Nitriles

Jih Ru Hwu, Chia Hao Hsu, Fong Fuh Wong et al. · Synthesis · 1998 · 15 citations

, , +6