Magnetite‐Loaded Polymeric Micelles as Ultrasensitive Magnetic‐Resonance Probes

Abstract

Increased contrast in magnetic resonance imaging (MRI) is accomplished using polymeric micelles loaded with superparamagnetic iron oxide (SPIO) nanoparticles encapsulated in biocompatible, biodegradable poly(ϵ-caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) copolymers (see Figure). The loaded micelles show significantly improved T2 relaxivities and remarkable MRI detection sensitivity. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2005/c1904_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.