Concepedia

Solid-phase synthesis of dual α4β1/α4β7 integrin antagonists: two scaffolds with overlapping pharmacophores

Georgette M. Castanedo, Fredrick C. Sailes, N. Dubree, John B. Nicholas, Lisa D. Caris, Kevin Clark, Susan M. Keating, Maureen H. Beresini, Henry Chiu, Sherman Fong,

Bioorganic & Medicinal Chemistry Letters · 2002 · 17 citations · 17 references

DOIFull text

Open access

Concepts

References

17

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

Mariano J. Elices, Laurelee Osborn, Yoshikazu Takada et al. · Cell · 1990 · 1.8K citations

, , +17

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

Ted Yednock, Catherine Cannon, Lawrence C. Fritz et al. · Nature · 1992 · 1.7K citations

, , +12

Expression of lymphocyte-endothelial receptor-ligand pairs, α4β7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease

Heitor Siffert Pereira de Souza, Celeste C. Elia, Jo Spencer et al. · Gut · 1999 · 219 citations · Full text

, , +17

Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation

Elaine M Connor, Michael J. Eppihimer, Zenichi Morise et al. · Journal of Leukocyte Biology · 1999 · 148 citations

, , +16

Amelioration of Murine Experimental Colitis by Inhibition of Mucosal Addressin Cell Adhesion Molecule-1

Shingo Kato, Ryota Hokari, Koji Matsuzaki et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 137 citations

, , +17