Concepedia

A CpG-containing oligodeoxynucleotide as an efficient adjuvant counterbalancing the Th1/Th2 immune response in diphtheria–tetanus–pertussis vaccine

Toshiyuki Sugai, Masaaki Mori, Masatoshi Nakazawa, Motohide Ichino, Takuya Naruto, Naoki Kobayashi, Yoshinori Kobayashi, Mutsuhiko Minami, Shumpei Yokota

Vaccine · 2005 · 68 citations · 39 references

DOI

Concepts

References

39

A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature · 2000 · 6.4K citations

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CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature · 1995 · 3.5K citations

, , +10

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

Dennis M. Klinman, Ae‐Kyung Yi, Serge L. Beaucage et al. · Proceedings of the National Academy of Sciences · 1996 · 1.5K citations

, , +17

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

Mark Roman, Elena Martín‐Orozco, Justin S. Goodman et al. · Nature Medicine · 1997 · 916 citations

, , +14

CpG DNA Is a Potent Enhancer of Specific Immunity in Mice Immunized with Recombinant Hepatitis B Surface Antigen

Heather L. Davis, Risini Weeranta, Thomas J. Waldschmidt et al. · The Journal of Immunology · 1998 · 681 citations · Full text

, , +17