International Journal of Immunogenetics · 2007 · 33 citations · 20 references
Life SciencesGeneticsImmunologyAllergyHypersensitivityImmunogeneticsAllergic DiseaseAllergic Disease PathologyCytokine Gene PolymorphismInterleukin Gene VariantsPopulation ImmunogeneticsRespiratory AllergyAllergic Airway InflammationAllergic Disease MechanismsAntigen Receptor PolymorphismGenetic PolymorphismsGenetic Susceptibility To AllergyHost Genetic PolymorphismsImmune Response Gene VariantsInterleukin Genetics
Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.
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