Reversal of the Swedish familial Alzheimer's disease mutant phenotype in cultured cells treated with phorbol 12,13-dibutyrate

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alison Goate, Marie‐Christine Chartier‐Harlin, Jeremy Brown et al. · Nature · 1991 · 4.6K citations

Life Sciences, Genetics, Molecular Genetics +16

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Jie Kang, Hans-Georg Lemaire, Axel Unterbeck et al. · Nature · 1987 · 4.6K citations

Life Sciences, Molecular Biology, Neuroscience +14

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Martin Citron, Tilman Oltersdorf, Christian Haass et al. · Nature · 1992 · 1.7K citations

Life Sciences, Molecular Biology, Neurology +16

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

Fiona Crawford, Karin Axelman, Henry Houlden et al. · Nature Genetics · 1992 · 1.5K citations

Life Sciences, Neurology, Neuroscience +17

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

Fred Esch, Pamela S. Keim, Eric C. Beattie et al. · Science · 1990 · 1.4K citations

Life Sciences, Biochemistry, Molecular Biology +17