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Molecular scanning of the insulin receptor substrate 1 gene in subjects with severe insulin resistance: detection and functional analysis of a naturally occurring mutation in a YMXM motif.

Insulin ResistanceMetabolic SyndromeGenetic DeterminantMolecular PhysiologySevere Insulin ResistanceG Protein-coupled ReceptorMedicineGeneticsDiabetesMolecular BiologyMolecular GeneticsInsulin ReceptorDisease Gene IdentificationYmxm MotifInsulin SignalingHealth Sciences