An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

Gout-associated uric acid crystals activate the NALP3 inflammasome

Fabio Martinon, Virginie Pétrilli, Annick Mayor et al. · Nature · 2006 · 5.2K citations

Life Sciences, Cell Biology, Immunology +11

Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study

Hilmar Wisplinghoff, Thomas Bischoff, Sandra Tallent et al. · Clinical Infectious Diseases · 2004 · 4.5K citations · Full text

Veterinary Medicine, Infectious Disease Control, Infectious Diseases +16

Cryopyrin activates the inflammasome in response to toxins and ATP

Sanjeev Mariathasan, David S. Weiss, Kim Newton et al. · Nature · 2006 · 3K citations

Life Sciences, Cell Biology, Molecular Biology +7

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Veit Hornung, Franz Bauernfeind, Annett Halle et al. · Nature Immunology · 2008 · 3K citations · Full text

Life Sciences, Cell Biology, Immunology +13

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Catherine Dostert, Virginie Pétrilli, Robin van Bruggen et al. · Science · 2008 · 2.7K citations · Full text

Veterinary Medicine, Immunology, Pathology +17