Journal of Natural Products · 2003 · 207 citations · 12 references
MedicineOncologyPharmacologyApoptosisCancer PharmacologyMolecular OncologyApoptosis In CancerApoptosis ModulationApoptosis PharmacologyApoptosis RegulationApoptotic SignalingOncology PharmacologyAnti-apoptotic AgentsAnticancer ActivityApoptosis In Cell CultureApoptosis Signaling In CancerApoptotic Signaling In CancerCancer Cell ApoptosisDrug-induced Apoptosis
We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.
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Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
Kam C. Yeung, Thomas Seitz, Shengfeng Li et al. · Nature · 1999 · 923 citations
Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
Setsuko Sahara, Mamoru Aoto, Yutaka Eguchi et al. · Nature · 1999 · 433 citations