Antimetastatic Role of Smad4 Signaling in Colorectal Cancer

Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

Yibin Kang, Wei He, Shaun Tulley et al. · Proceedings of the National Academy of Sciences · 2005 · 533 citations · Full text

Medicine, Molecular Biology, Oncology +17

Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

Michiko Miyaki, Takeru Iijima, Motoko Konishi et al. · Oncogene · 1999 · 435 citations

Medicine, Genetics, Oncology +15

LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

Davide Melisi, Satoshi Ishiyama, Guido M. Sclabas et al. · Molecular Cancer Therapeutics · 2008 · 317 citations · Full text

Medicine, Oncology, Pharmacology +17

A Specific Inhibitor of TGF-β Receptor Kinase, SB-431542, as a Potent Antitumor Agent for Human Cancers

Sunil K. Halder, R. Daniel Beauchamp, Pran K. Datta · Neoplasia · 2005 · 286 citations · Full text

Medicine, Oncology, Pharmacology +16

Blocking transforming growth factor–beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells

Emilia Fransvea, Umberto Filippo Angelotti, Salvatore Antonaci et al. · Hepatology · 2008 · 252 citations

Medicine, Oncology, Pharmacology +15