Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

Genetic Alterations during Colorectal-Tumor Development

Bert Vogelstein, Eric R. Fearon, Stanley R. Hamilton et al. · New England Journal of Medicine · 1988 · 6.8K citations

Medicine, Genetics, Oncology +14

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

Masato Orita, Youichi Suzuki, Takao Sekiya et al. · Genomics · 1989 · 3.5K citations

Life Sciences, Genetics, Molecular Genetics +16

<i>DPC4</i> , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

Stephan A. Hahn, Mieke Schutte, A.T.M. Shamsul Hoque et al. · Science · 1996 · 2.3K citations

Medicine, Genetics, Oncology +17

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

Atsuhito Nakao, Mozhgan Afrakhte, Anita Morn et al. · Nature · 1997 · 1.8K citations

Life Sciences, Molecular Biology, Cell Signaling +8

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

Eric R. Fearon, Kathleen R. Cho, Janice Nigro et al. · Science · 1990 · 1.7K citations

Life Sciences, Genetics, Oncology +17