Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.2K citations

Life Sciences, Biotechnology, Molecular Biology +12

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

David Botstein, R. White, Mark H. Skolnick et al. · PubMed · 1980 · 8.4K citations

Life Sciences, Genetics, Molecular Genetics +13

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa et al. · Proceedings of the National Academy of Sciences · 1989 · 3.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

A general method for isolation of high molecular weight DNA from eukaryotes

Nikolaus Blin, Darrel W. Stafford · Nucleic Acids Research · 1976 · 2.8K citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

Ulf Gyllensten · Proceedings of the National Academy of Sciences · 1988 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17