IL‐18 gene polymorphism confers susceptibility to the development of anti‐GAD65 antibody in Graves’ disease

Abstract

These findings in a Japanese population indicate that Graves' disease patients carrying the GG genotype at position -4657 of the promoter of the IL-18 gene or a gene in linkage disequilibrium with the -4675G/-607A/-137G haplotype have a low risk for the development of GAD65Ab in Graves' disease.