Involvement of a p38 Mitogen-activated Protein Kinase Phosphatase in Protecting Neonatal Rat Cardiac Myocytes from Ischemia

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

Life Sciences, Immunology, Molecular Biology +14

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

Ana Cuenda, J.B. Rouse, Yair N. Doza et al. · FEBS Letters · 1995 · 2.1K citations

Life Sciences, Molecular Biology, Pharmacology +14

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

Hong Sun, Catherine H. Charles, Lester F. Lau et al. · Cell · 1993 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +13

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

Yibin Wang, Shuang Huang, Valerie P. Sah et al. · Journal of Biological Chemistry · 1998 · 855 citations · Full text

Life Sciences, Cell Biology, Physiology +14

Inhibition of p38 Mitogen-Activated Protein Kinase Decreases Cardiomyocyte Apoptosis and Improves Cardiac Function After Myocardial Ischemia and Reperfusion

Xin L., Sanjay Kumar, Feng Gao et al. · Circulation · 1999 · 501 citations · Full text

Medicine, Cardiology, Pharmacology +14