A novel immunosuppressant, FTY720, induces peripheral lymphodepletion of both T- and B cells and immunosuppression in baboons

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

Kenji Chiba, Yoshiki Yanagawa, Yumi Masubuchi et al. · The Journal of Immunology · 1998 · 596 citations

Life Sciences, Immunology, Pharmacology +15

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

Kunitomo Adachi, Toshiyuki Kohara, Noriyoshi Nakao et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 308 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

A NOVEL IMMUNOSUPPRESSANT, FTY720, WITH A UNIQUE MECHANISM OF ACTION, INDUCES LONG-TERM GRAFT ACCEPTANCE IN RAT AND DOG ALLOTRANSPLANTATION1

Seiichi Suzuki, Shin Enosawa, Toshihiro Kakefuda et al. · Transplantation · 1996 · 292 citations

Medicine, Cell Biology, Pharmacology +16

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. II. FTY720 Prolongs Skin Allograft Survival by Decreasing T Cell Infiltration into Grafts But Not Cytokine Production In Vivo

Yoshiki Yanagawa, Kunio Sugahara, Hirotoshi Kataoka et al. · The Journal of Immunology · 1998 · 262 citations · Full text

Life Sciences, Immunology, Pharmacology +16

FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats.

Kenji Chiba, Yukio Hoshino, Yuji Masubuchi et al. · PubMed · 1996 · 128 citations

Medicine, Immunology, Pharmacology +15