Effect of CYP2B6*6 and CYP2C19*2 genotype on chlorpyrifos metabolism

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

Thomas Lang, Kathrin Klein, Joachim E. Fischer et al. · Pharmacogenetics · 2001 · 569 citations

Medicine, Genetics, Molecular Genetics +17

Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity

Stephanie Faucette, Roy L. Hawke, Edward L. LeCluyse et al. · Drug Metabolism and Disposition · 2000 · 356 citations

Medicine, Biochemistry, Pharmacology +17

Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations

Joyce A. Goldstein, Takashi Ishizaki, Kan Chiba et al. · Pharmacogenetics · 1997 · 353 citations

Life Sciences, Genetics, Pharmacology +17

A Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Model for the Organophosphate Insecticide Chlorpyrifos in Rats and Humans

Charles Timchalk · Toxicological Sciences · 2002 · 281 citations · Full text

Pharmacy, Pharmacokinetics, Toxicology +17

Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine

Tanja Richter, Thomas E. Mürdter, Georg Heinkele et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 260 citations

Medicine, Pharmacokinetics, Pharmacology +17