Concepedia

Publication | Closed Access

Glyburide and glimepiride pharmacokinetics in subjects with different <i>CYP2C9</i> genotypes

DOI

171

Citations

0

References

2002

Year

Mikko Niemi, Ingolf Cascorbi, Ramona Timm, Heyo K. Kroemer, Pertti J. Neuvonen, Kari T. Kivistö
Clinical Pharmacology & Therapeutics

Abstract

Genetic polymorphisms of CYP2C9 markedly affect the pharmacokinetics of both glyburide and glimepiride. The influence of the CYP2C9*3 variant allele on glyburide and glimepiride pharmacokinetics may be clinically significant.