Concepedia

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins

Thomas Schweins, Matthias Geyer, Klaus Scheffzek, Arieh Warshel, Hans Robert Kalbitzer, Alfred Wittinghofer

Nature Structural Biology · 1995 · 274 citations · 50 references

DOI

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References

50

Mammalian Ras interacts directly with the serine/threonine kinase raf

Anne B. Vojtek, Stanley M. Hollenberg, Jonathan A. Cooper · Cell · 1993 · 2K citations

, , +14

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

Claudia A. Landis, Susan B. Masters, Anna Spada et al. · Nature · 1989 · 1.4K citations

, , +16

Refined crystal structure of the triphosphate conformation of H‐ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

E.F. Pai, Ute Krengel, Gregory A. Petsko et al. · The EMBO Journal · 1990 · 1.1K citations · Full text

, , +14

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic <i>ras</i> Proteins

Michael V. Milburn, Liang Tong, Abraham M. deVos et al. · Science · 1990 · 1.1K citations

, , +17

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

E.F. Pai, Wolfgang Kabsch, Ute Krengel et al. · Nature · 1989 · 889 citations

, , +12