Organic Letters · 2013 · 18 citations · 34 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryCarbonyl ChemistryDiversity-oriented SynthesisHeterocycle SynthesisMacrocycle SynthesisOrganic SynthesisAsymmetric Heterocycle SynthesisChiral Intermediate ProductionDiversity-oriented Heterocycle SynthesisHeterocycle FunctionalizationMedicinal HeterocyclesMild Reaction ConditionsNitrogen HeterocyclesOxygen Heterocycles
The carbonyl ene reaction of 2-methylenetetrahydropyrans provides a rapid, high yielding route for the preparation of β-hydroxydihydropyrans under mild conditions. This process provides a new entry for the synthesis of 2-substituted tetrahydropyrans and for the direct introduction of oxygen heterocycles into molecular frameworks.
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