Concepedia

Synthesis and Biological Evaluation of Highly Functionalized Analogues of Ingenol

Jeffrey D. Winkler, Sanghee Kim, Sean Harrison, Nancy E. Lewin, Peter M. Blumberg

Journal of the American Chemical Society · 1998 · 25 citations · 8 references

DOI

Concepts

Abstract

The synthesis and preliminary biological evaluation of the first analogues of ingenol, a potent activator of protein kinase C, containing all of the oxygen functionality and unsaturation present in the natural product, is described.

References

8

The MARCKS family of cellular protein kinase C substrates.

Perry J. Blackshear · Journal of Biological Chemistry · 1993 · 480 citations · Full text

, , +13

Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.

Paul A. Wender, C. M. CRIBBS, Konrad F. Koehler et al. · Proceedings of the National Academy of Sciences · 1988 · 201 citations · Full text

, , +17

Computer-assisted molecular modeling of tumor promoters: rationale for the activity of phorbol esters, teleocidin B, and aplysiatoxin.

A. M. Jeffrey, Rob M. J. Liskamp · Proceedings of the National Academy of Sciences · 1986 · 114 citations · Full text

, , +16

From Bench Top to Bedside

Marcia Barinaga · Science · 1997 · 96 citations

, , +17

Structural basis of protein kinase C activation by tumor promoters.

Hiroyuki Nakamura, Yoshito Kishi, Marı́a A. Pajares et al. · Proceedings of the National Academy of Sciences · 1989 · 85 citations · Full text

, , +16