Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

Robert Esnouf, Jingshan Ren, Carl Ross et al. · Nature Structural & Molecular Biology · 1995 · 441 citations

Life Sciences, Molecular Biology, Pharmacology +14

Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors

Andrew L. Hopkins, Jingshan Ren, Robert Esnouf et al. · Journal of Medicinal Chemistry · 1996 · 343 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative

Masanori Baba, H. TANAKA, Erik De Clercq et al. · Biochemical and Biophysical Research Communications · 1989 · 288 citations

Medicine, Medicinal Chemistry, Pharmacology +9

5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3,4-dihydropyrimidin-4(3<i>H</i>)-ones:  Novel Potent and Selective Dihydro-alkoxy-benzyl-oxopyrimidine Derivatives

Antonello Mai, Marino Artico, Gianluca Sbardella et al. · Journal of Medicinal Chemistry · 1999 · 104 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Dihydro(alkylthio)(naphthylmethyl)oxopyrimidines:  Novel Non-Nucleoside Reverse Transcriptase Inhibitors of the <i>S</i>-DABO Series

Antonello Mai, Marino Artico, Gianluca Sbardella et al. · Journal of Medicinal Chemistry · 1997 · 98 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17