Concepedia

Both Paraoxonase-1 Genotype and Activity Do Not Predict the Risk of Future Coronary Artery Disease; the EPIC-Norfolk Prospective Population Study

Rakesh S. Birjmohun, Menno Vergeer, Erik S.G. Stroes, Manjinder S. Sandhu, Sally L. Ricketts, Michael W.T. Tanck, Nicholas J. Wareham, J. Wouter Jukema, John J.P. Kastelein, Kay‐Tee Khaw,

PLoS ONE · 2009 · 64 citations · 38 references

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Abstract

This study, shows that PON1-activity inversely relates to CAD risk, but not independent of HDL, due to its close association with the HDL-particle. These data strongly suggest that a low PON1-activity is not a causal factor in atherogenesis.

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New England Journal of Medicine · 2006 · 1.7K citations · Full text