Ophthalmic Research · 2009 · 35 citations · 0 references
MedicineBiochemistryOphthalmologyOphthalmic SurgeryRegenerative MedicineTissue EngineeringCollagen DepositionCorneal PathologyCorneal PhysiologyCorneal Tissue EngineeringCorneal TraumaCorneal Wound HealingAscorbate MetabolismAscorbic Acid TreatmentCorneal Epithelial HealingCorneal Healing ResponseCorneal Stromal Cell BiologyCorneal Stromal DegenerationCorneal Stromal DiseaseType Iii Collagen Deposition
We studied the effect of L-ascorbic acid 2-phosphate (P-Asc), a long-acting phosphate derivative of L-ascorbic acid, on the production and secretion of type I and type III collagen peptides in cultured rabbit keratocytes using immunohistochemistry and enzyme immunoassay. P-Asc enhanced production and secretion of these collagen peptides. Our observations support a therapeutic role for P-Asc in the repair of corneal stromal damage such as caused by corneal chemical burn.