Annals of the New York Academy of Sciences · 1972 · 108 citations · 31 references
MedicineBiochemistryPharmacologyCell SignalingHemostasisSignal TransductionCyclic Nucleotide SignalingPlatelet ActivationPlatelet AggregationPlatelet FunctionPlatelet PhysiologyThrombin GenerationAntiplatelet DrugsCyclic Adenosine Monophosphate SignalingCyclic Nucleotide SynthesisPhosphodiesterase RegulationPhosphodiesterase SignalingPlatelet Aggregation InhibitionPlatelet InhibitionPlatelet Metabolism
Evidence which bears on the hypothesis that agents that increase platelet cyclic adenosine 3',5' monophosphate (cAMP) tend to inhibit platelet aggregation, whereas agents whose action is to induce or augment platelet aggregation are associated with a decrease in platelet content of this cyclic nucleotide is reviewed. Using radiolabeled cAMP in incubation with various agents, it was found that caffeine, colagen, thrombin, prostaglandins E1 and E2, and phosphodiesterase inhibitors are all agents that increase platelet cAMP and inhibit platelet aggregation.
31