Overexpression of Human CAP10-Like Protein 46 KD in T-Acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia

Abstract

Considering that hCLP46 has the capability of modifying the Notch pathway, our finding adds weight to the importance of Notch signaling in hematopoiesis and suggests that overexpression of hCLP46 might be an early event in the pathogenesis of AML and T-ALL.