Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant‐negative, or hypomorphic alleles

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Life Sciences, Biochemistry, Cell Biology +16

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

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Life Sciences, Genetics, Molecular Biology +16

Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia

Stefan Mundlos, F Otto, C Mundlos et al. · Cell · 1997 · 1.5K citations · Full text

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Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome

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Life Sciences, Genetics, Molecular Genetics +13

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

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Life Sciences, Genetics, Molecular Genetics +14