Concepedia

Dominant Negative Mutations

Dominant Negative Mutations is a genetic phenomenon in which a mutant allele produces a dysfunctional protein that interferes with the function of the wild-type protein encoded by the normal allele, thereby exerting a dominant inhibitory effect on the phenotype.

1.7K

Publications

151.4K

Citations

10.2K

Authors

1.9K

Institutions

Publications per year

2017–2026

162

Variants

Dominant Negative Mutation

Parents

Publications

1.7K

A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei

Elizabeth Wirtz, Simone Leal, Claudia M. Ochatt et al. · Molecular and Biochemical Parasitology · 1999 · 1.5K citations

, , +17

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

Inês Barroso, Mark Gurnell, Vivion Crowley et al. · Nature · 1999 · 1.4K citations

, , +12

Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

Jawed Alam, Daniel P. Stewart, Cheri Touchard et al. · Journal of Biological Chemistry · 1999 · 1.3K citations · Full text

, , +16

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

B Millauer, Laura K. Shawver, Karl H. Plate et al. · Nature · 1994 · 1.2K citations

, , +12

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

Enrique Amaya, Thomas J. Musci, Marc W. Kirschner · Cell · 1991 · 1.1K citations

, , +16

1–5 of 1.7K

Authors

10.2K

  1. SC
    Sheue-yann Cheng

    National Cancer Institute, United States

    9 publications · 510 citations

    9

    h-index

  2. CC
    Cong Cao

    Soochow University, China

    7 publications · 325 citations

    7

    h-index

  3. JL
    Johannes L. Bos

    Utrecht University, Netherlands

    7 publications · 557 citations

    7

    h-index

  4. JC
    Jean‐Laurent Casanova

    Inserm, France

    7 publications · 926 citations

    7

    h-index

  5. JA
    Joseph A. Marsh

    University of Edinburgh, United Kingdom

    5 publications · 496 citations

    5

    h-index

1–5 of 10.2K

Institutions

1.9K

  1. Harvard University

    Cambridge, United States

    49 h-index

    262 publications

    47.3K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    48 h-index

    168 publications

    28K citations

  3. National Institutes of Health

    Bethesda, United States

    41 h-index

    225 publications

    30K citations

  4. Inserm

    Paris, France

    38 h-index

    301 publications

    32K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    32 h-index

    223 publications

    15K citations

  6. Johns Hopkins University

    Baltimore, United States

    29 h-index

    106 publications

    18.6K citations

  7. University of California, San Francisco

    San Francisco, United States

    28 h-index

    104 publications

    12.7K citations

  8. University of Pennsylvania

    Philadelphia, United States

    27 h-index

    97 publications

    17.5K citations

1–8 of 1.9K

Venues

  1. Journal of Biological Chemistry

    JBC · 149 publications · 14.7K citations

    70

    h-index

  2. Molecular and Cellular Biology

    MCB · 101 publications · 13.6K citations

    63

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 81 publications · 10.7K citations

    58

    h-index

  4. Human Molecular Genetics

    54 publications · 5.1K citations

    39

    h-index

  5. PubMed

    Repository · 56 publications · 4K citations

    36

    h-index

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