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The Stimulatory Adenosine Receptor ADORA2B Regulates Serotonin (5-HT) Synthesis and Release in Oxygen-Depleted EC Cells in Inflammatory Bowel Disease

DOIFull Paper Access

24

Citations

42

References

2013

Year

Rikard Damen, Martin Haugen, Bernhard Svejda, Daniele Alaimo, Øystein Brenna, Roswitha Pfragner, Bjørn I. Gustafsson, Mark Kidd
PLoS ONE

Abstract

Hypoxia induced 5-HT synthesis and secretion is amplified by ADORA2B signaling via MAPK/CREB and TPH-1 activation. Targeting ADORA2s may decrease EC cell 5-HT production and secretion in IBD.

References

YearCitations

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