Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

Paul F. Jacques, Andrew G. Bostom, Roger R. Williams et al. · Circulation · 1996 · 1.4K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status

Simonetta Friso, Sang‐Woon Choi, Domenico Girelli et al. · Proceedings of the National Academy of Sciences · 2002 · 931 citations

Medicine, Genetics, Molecular Genetics +17

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

Zhuo Chen · Human Molecular Genetics · 2001 · 618 citations

Life Sciences, Genetics, Molecular Genetics +15

A Common Variant in Methionine Synthase Reductase Combined with Low Cobalamin (Vitamin B12) Increases Risk for Spina Bifida

Aaron Wilson, Robert W. Platt, Qing Wu et al. · Molecular Genetics and Metabolism · 1999 · 440 citations

Life Sciences, Biochemistry, Genetics +17

Deaths: final data for 2002.

Kenneth D. Kochanek, Sherry L Murphy, Robert N. Anderson et al. · PubMed · 2004 · 388 citations

Social Sciences, Demography, Epidemiology +16