Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor

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Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

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Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

Julian Adams, Mark L. Behnke, Shaowu Chen et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 683 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +12

Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome

Francesco Parlati, Monette Aujay, Érika Suzuki et al. · Blood · 2009 · 323 citations

Life Sciences, Biochemistry, Oncology +11

A Phase 1 Dose Escalation Study of the Safety and Pharmacokinetics of the Novel Proteasome Inhibitor Carfilzomib (PR-171) in Patients with Hematologic Malignancies

Owen A. O’Connor, A. Keith Stewart, Marcy K. Vallone et al. · Clinical Cancer Research · 2009 · 301 citations · Full text

Medicine, Oncology, Pharmacology +15