Effective therapy for nephritis in (NZB × NZW)F₁ mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy <i>Tripterygium wilfordii</i> Hook F

Abstract

Therapy with triptolide or tripdiolide significantly ameliorated lupus nephritis in (NZB x NZW)F1 mice, reduced cytokine and chemokine production, and prolonged survival.