Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

Xueling Wu, Zhi-Yong Yang, Yuxing Li, +21

Science

Broad Hiv-1 NeutralizationEngineeringRational DesignMedicineHuman Retrovirus +12

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

Jinghe Huang, Gilad Ofek, Leo Laub, +17

Nature

Potent NeutralizationHuman RetrovirusImmunologyAntiviral ResponseAntibody Engineering +6

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Xueling Wu, Tongqing Zhou, Jiang Zhu, +25

Science

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Nicole A. Doria‐Rose, Chaim A. Schramm, Jason Gorman, +29

Nature

Developmental PathwayHuman RetrovirusImmunologyAntiviral ResponseVirology +3

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

Tongqing Zhou, Jiang Zhu, Xueling Wu, +30

Immunity

Virus StructureHuman RetrovirusHiv-1 NeutralizationImmunologyMaturation Pathway +10

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

Tongqing Zhou, Rebecca M. Lynch, Lei Chen, +48

Cell

Human RetrovirusCd4 SupersiteImmunologyStructural RepertoireMolecular Biology +10

Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens

Xiaodong Xiao, Weizao Chen, Yang Feng, +6

Biochemical and Biophysical Research Communications

VaccinationVaccine TargetHuman RetrovirusImmunologyAntiviral Response +9

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

Xueling Wu, Zhenhai Zhang, Chaim A. Schramm, +17

Cell

Primary ImmunodeficiencyVrc01-antibody LineageHuman RetrovirusImmunologyAntiviral Response +6

Isolation of human monoclonal antibodies from peripheral blood B cells

Jinghe Huang, Nicole A. Doria‐Rose, Nancy S. Longo, +7

Nature Protocols

Autoimmune DiseaseHumoral ResponseHematologyImmunologyPathology +10

Characterization of the Human Ig Heavy Chain Antigen Binding Complementarity Determining Region 3 Using a Newly Developed Software Algorithm, JOINSOLVER

Margarida Souto‐Carneiro, Nancy S. Longo, D. Russ, +2

The Journal of Immunology

HistocompatibilityProductive RepertoireGeneticsImmunologyPathology +16