Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Rudi Pauwels, Jan Balzarini, Masanori Baba et al. · Journal of Virological Methods · 1988 · 1.6K citations

Life Sciences, Infectious Diseases, Analytical Chemistry +12

Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial

Beatriz Grinsztejn, Bach-Yen Nguyen, Christine Katlama et al. · The Lancet · 2007 · 568 citations · Full text

Pharmacy, Clinical Pharmacokinetics, Infectious Diseases +16

Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA.

Frederic D. Bushman, Robert Craigie · Proceedings of the National Academy of Sciences · 1991 · 408 citations

Life Sciences, Molecular Biology, Molecular Genetics +11

Antiretroviral Activity, Pharmacokinetics, and Tolerability of MK-0518, a Novel Inhibitor of HIV-1 Integrase, Dosed As Monotherapy for 10 Days in Treatment-Naive HIV-1-Infected Individuals

Martin Markowitz, Javier O Morales-Ramirez, Bach‐Yen Nguyen et al. · JAIDS Journal of Acquired Immune Deficiency Syndromes · 2006 · 366 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Susceptibility of HIV-2, Siv and Shiv to Various Anti-HIV-1 Compounds: Implications for Treatment and Postexposure Prophylaxis

Myriam Witvrouw, Christophe Pannecouque, William M. Switzer et al. · Antiviral Therapy · 2004 · 269 citations

Medicine, Infectious Diseases, Pharmacology +17