TUMOR IMAGING WITH [111ⁿⁱIn]MONO‐DTPA‐ETHYLENEGLYCOL‐Ga‐DEUTEROPORPHYRIN

Abstract

Abstract Mono‐DPTA‐ethyleneglycol‐Ga‐deuteroporphyrin (MDEGD) was synthesized, by coordinating non‐radioactive Ga in the porphyrin ring and connecting DTPA (diethylene‐triamine‐N,N,N,N,N,‐pentaacetic acid) to its side chain. By labeling with 111 In , chemicals for scintigraphy were developed. They were applied to Syrian golden hamsters with implanted pancreatic gland cancers and C57‐black mice with Lewis lung cancer to enable tumor imaging and biodistribution examination. A comparative study was also conducted with [ 67 Ga]citrate. In the resultant data, [ 111 In]MDEGD showed larger tumor/lung, tumor/kidney and tumor/blood ratio with [ 67 Ga]citrate. The affinity of [ n In]MDEGD in inflammatory tissue was much lower than that of 67 Ga citrate. [ 111 In]MDEGD lost its photosensitivity.