Delineation of a transplanted malignant melanoma with indium-111-labeled porphyrin.

Abstract

An indium complex of a cationic, water-soluble, synthetic porphyrin, tetra-4-N-methylpyridyl porphyrin tosylate, has been prepared and evaluated for its selective localization in tumors in Syrian Golden hamsters with flank transplanted malignant melanoma (Fortner MMI). Tumor-to-blood ratios of the compound increase from 42:1 at 6 hr postinjection, at which time activity levels in the tumor exceed those in all other tissues, to 162.1 at 72 hr. Images in one hamster at three time periods clearly delineated the tumor from nontarget background and also demarcated the viable and necrotic zones within the tumor itself.