The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Paola Scaffidi, Tom Misteli, Marco E. Bianchi · Nature · 2002 · 4.1K citations

Inflammation, Chromatin, Cytokine +10

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

Haichao Wang, Ona Bloom, Minghuang Zhang et al. · Science · 1999 · 3.4K citations

Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States

George Ostapowicz, Robert J. Fontana, Frank Vinholt Schiødt et al. · Annals of Internal Medicine · 2002 · 2.2K citations

Molecular identification of a danger signal that alerts the immune system to dying cells

Yan Shi, James Evans, Kenneth L. Rock · Nature · 2003 · 1.6K citations

Inflammation, Immune Evasion, Systems Biology +14

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

Alexzander Asea, Stine‐Kathrein Kraeft, Evelyn A. Kurt‐Jones et al. · Nature Medicine · 2000 · 1.6K citations

Inflammation, Cytokine, Autoimmune Disease +12