PLoS ONE · 2014 · 33 citations · 53 references
Life SciencesCell BiologyMolecular BiologyApoptosisGene ExpressionMolecular Cell BiologyApoptosis ResistanceCellular Responses To HypoxiaDna Damage SignalingHypoxia AdaptationStress Signaling PathwaysStress-responsive Gene RegulationCell Survival AssaysCellular Hypoxia SignalingCellular Stress AdaptationCellular Stress SignalingDna Damage InductionHypoxia-induced Apoptosis ResistanceHypoxia-induced Gene ExpressionHypoxia-induced Signaling
N-myc downstream-regulated gene 1 (NDRG1) is induced by cellular stress such as hypoxia and DNA damage, and in humans, germ line mutations cause Charcot-Marie-Tooth disease. However, the cellular roles of NDRG1 are not fully understood. Previously, NDRG1 was shown to mediate doxorubicin resistance under hypoxia, suggesting a role for NDRG1 in cell survival under these conditions. We found decreased apoptosis in doxorubicin-treated cells expressing NDRG1 shRNAs under normoxia, demonstrating a requirement for NDRG1 in apoptosis in breast epithelial cells under normal oxygen pressure. Also, different cellular stress regimens, such as hypoxia and doxorubicin treatment, induced NDRG1 through different stress signalling pathways. We further compared expression profiles in human breast epithelial cells ectopically over-expressing NDRG1 with cells expressing NDRG1 shRNAs in order to identify biological pathways where NDRG1 is involved. The results suggest that NDRG1 may have roles connected to vesicle transport.
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In silico prediction of protein-protein interactions in human macrophages
Oussema Souiai, Fatma Z. Guerfali, Slimane Ben Miled et al. · BMC Research Notes · 2014 · 11K citations · Full text
GoMiner: a resource for biological interpretation of genomic and proteomic data
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