Enantiopure DAVA-derivatives-part III. Synthesis of all 4 stereoisomers of 2-methyl-4-hydroxy-5-aminopentanoic acid (2-Me-4-OH-DAVA).

Phaclofen: a peripheral and central baclofen antagonist

David I.B. Kerr, Jennifer Ong, Rolf H. Prager et al. · Brain Research · 1987 · 349 citations

Medicine, Pharmacology, Pharmacotherapy +4

CGP 35348: a centrally active blocker of GABAB receptors

Hans-Rudolf Olpe, Göril Karlsson, Mario F. Pozza et al. · European Journal of Pharmacology · 1990 · 309 citations

Medicine, Neuroscience, Pharmacology +16

2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors

David I.B. Kerr, Jennifer Ong, Graham A.R. Johnston et al. · Neuroscience Letters · 1988 · 205 citations

Medicine, Neurobiology, Pharmacology +14

Synthesis of the enantiomers of 4-substituted γ-lactones with known absolute configuration

Uzi Ravid, Robert M. Silverstein, Leverett R. Smith · Tetrahedron · 1978 · 195 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Stereochemical control of nature's biosynthetic pathways:A general strategy for the synthesis 0f polypropionate-derived structural units from a single chiral progenitor

Stephen Hanessian, Peter Murray · Tetrahedron · 1987 · 99 citations

Pharmacy, Chemical Engineering, Natural Product Biosynthesis +13