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Novel dihydrothieno[2,3-e]indazole derivatives as IκB kinase inhibitors

Hiroyasu Takahashi, Mariko Shinoyama, Takashi Komine, Muneki Nagao, Masashi Suzuki, H. Tsuchida, Koichi Katsuyama

Bioorganic & Medicinal Chemistry Letters · 2011 · 12 citations · 7 references

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7

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

Mireille Delhase, Makio Hayakawa, Yi Chen et al. · Science · 1999 · 869 citations

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Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors

Andrew Baxter, Steve Brough, Anne Cooper et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 91 citations

, , +14

IκB Kinase-2-Independent and -Dependent Inflammation in Airway Disease Models: Relevance of IKK-2 Inhibition to the Clinic

Mark A. Birrell, Sissie Wong, Elizabeth Hardaker et al. · Molecular Pharmacology · 2006 · 58 citations

, , +17

Inhibition of IKK-2 by 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides

D. Bonafoux, Sheri L. Bonar, Lori J. Christine et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 30 citations · Full text

, , +4

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors

John Liddle, Paul Bamborough, Michael D. Barker et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 28 citations · Full text

, , +9