Solvent-free synthesis of 1,4-disubstituted 1,2,3-triazoles using a low amount of Cu(PPh3)2NO3 complex

Abstract

We have developed an environmentally friendly and highly efficient method for copper-catalyzed cycloaddition of organic azides and terminal alkynes under solvent-free conditions. The protocol uses the cheap and easy-to-prepare Cu(PPh3)2NO3 complex as the catalyst.