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Changes in thymidylate synthase and its inhibition rate and changes in dihydropyrimidine dehydrogenase after the administration of 5-fluorouracil with cisplatin to nude mice with gastric cancer xenograft SC-1-NU

Yoichi Sakurai, Takashi Uraguchi, Hiroki Imazu, Shigeru Hasegawa, Toshiki Matsubara, Masahiro Ochiai, Takahiko Funabiki

Gastric Cancer · 2004 · 17 citations · 26 references

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26

PROTOCOLS FOR SCREENING CHEMICAL AGENTS AND NATURAL PRODUCTS AGAINST ANIMAL TUMORS AND OTHER BIOLOGICAL SYSTEMS

Ruth I. Geran, Nathaniel H. Greenberg, Marylea MacDonald et al. · Cancer chemotherapy reports. Part 1 · 1972 · 1.1K citations

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Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators

Tetsuhiko Shirasaka, Yuji Shimamato, Hideyuki Ohshimo et al. · Anti-Cancer Drugs · 1996 · 824 citations

, , +16

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

P. G. Johnston, Heinz-Josef Lenz, Cynthia G. Leichman et al. · PubMed · 1995 · 678 citations

, , +17

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate

Daniel V. Santi, Charles S. McHenry, Hans Sommer · Biochemistry · 1974 · 621 citations

, , +5

Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1M tegafur–0.4M gimestat–1M otastat potassium) in advanced gastric cancer patients

Yuh Sakata, Atsushi Ohtsu, N Horikoshi et al. · European Journal of Cancer · 1998 · 564 citations

, , +11