ADP Receptor P2Y ₁₂ Is Expressed in Vascular Smooth Muscle Cells and Stimulates Contraction in Human Blood Vessels

Abstract

ADP acting on P2Y12 receptors not only is important for platelet activation but also stimulates vasoconstriction. Stable drugs with antagonistic effects on P2Y12 receptors, affecting both platelets and VSMC, could be of double therapeutic benefit in their prevention of both thrombosis and vasospasm.