Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

Jan E. Carette, Matthijs Raaben, Anthony Wong et al. · Nature · 2011 · 1.3K citations · Full text

Life Sciences, Infectious Diseases, Microbiology +12

Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes

Ruth I. Connor, Benjamin K. Chen, Sunny Choe et al. · Virology · 1995 · 1.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +16

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

Ilona Glowacka, Stephanie Bertram, Marcel A. Müller et al. · Journal of Virology · 2011 · 1.2K citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

Graham Simmons, Dhaval N. Gosalia, Andrew J. Rennekamp et al. · Proceedings of the National Academy of Sciences · 2005 · 1.1K citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

Shutoku Matsuyama, Noriyo Nagata, Kazuya Shirato et al. · Journal of Virology · 2010 · 846 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17