Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

Ilona Glowacka, Stephanie Bertram, Marcel A. Müller, +10

Journal of Virology

Membrane FusionProtease InhibitorsHumoral Immune ResponseBiochemistryReduces Viral Control +13

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

Ilona Glowacka, Stephanie Bertram, Petra Herzog, +10

Journal of Virology

Acute Lung InjuryViral ReplicationHuman Coronavirus Nl63ImmunologyViral Pathogenesis +15

TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium

Stephanie Bertram, Ronald Dijkman, Matthias Habjan, +9

Journal of Virology

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

Stephanie Bertram, Ilona Glowacka, Marcel A. Müller, +10

Journal of Virology

Protease InhibitorsVirus StructureHat ExpressionMolecular VirologyAllergy +10

Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin

Chawaree Chaipan, Darwyn Kobasa, Stephanie Bertram, +9

Journal of Virology

Ha-processing Protease Tmprss2Influenza Virus HemagglutininMolecular VirologyMedicineNatural Sciences +9

TMPRSS2 and TMPRSS4 Facilitate Trypsin-Independent Spread of Influenza Virus in Caco-2 Cells

Stephanie Bertram, Ilona Glowacka, Paulina Błażejewska, +9

Journal of Virology

A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms

Yanchen Zhou, Kai Lü, Susanne Pfefferle, +5

Journal of Virology

Complement SystemMultiple MechanismsPathogenesisImmunologyGlycobiology +10

Different host cell proteases activate the SARS-coronavirus spike-protein for cell–cell and virus–cell fusion

Graham Simmons, Stephanie Bertram, Ilona Glowacka, +8

Virology

Viral ReplicationSars-coronavirus Spike-proteinVirus–cell FusionViral PathogenesisVirology +5

Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression

Kerstin Gnirß, Annika Kühl, Christina B. Karsten, +5

Virology

Molecular VirologyCathepsins BPathogenesisViral PathogenesisImmunology +7

The Ebola Virus Glycoprotein and HIV-1 Vpu Employ Different Strategies to Counteract the Antiviral Factor Tetherin

Annika Kühl, Carina Banning, Andrea Marzi, +12

The Journal of Infectious Diseases

Tetherin InhibitionInhibit TetherinImmunologyAntiviral ResponseAntiviral Therapy +11