Control of CNS Cell-Fate Decisions by SHP-2 and Its Dysregulation in Noonan Syndrome

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

Marco Tartaglia, Ernest L. Mehler, Rosalie Goldberg et al. · Nature Genetics · 2001 · 1.7K citations

Molecular Physiology, Signal Transduction, Genetic Disorder +8

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

Karl Johe, Thomas G. Hazel, Thomas Müller et al. · Genes & Development · 1996 · 1.2K citations · Full text

Adult Stem Cell, Stem Cell Differentiation, Cerebral Organoid +18

Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway

Azad Bonni, Yi Eve Sun, Mireya Nadal‐Vicens et al. · Science · 1997 · 1K citations

Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

Todd E. Golde, Steven Estus, M. Usiak et al. · Neuron · 1990 · 433 citations

Neurodegenerative Diseases, Alzheimer's Disease, Spliced Form +6

Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

Toshiyuki Araki, M. Golam Mohi, Fraz A. Ismat et al. · Nature Medicine · 2004 · 417 citations

Ptpn11 Mutation, Genetic Disorder, Genetics +8