Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

Marco Tartaglia, Ernest L. Mehler, Rosalie Goldberg et al. · Nature Genetics · 2001 · 1.7K citations

Molecular Physiology, Signal Transduction, Genetic Disorder +8

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

Lori D. Klaman, Olivier Boss, Odile D. Peroni et al. · Molecular and Cellular Biology · 2000 · 1.2K citations · Full text

Metabolic Disorder, Energy Expenditure, Tissue-specific Insulin Sensitivity +19

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

Marco Tartaglia, Charlotte M. Niemeyer, Alessandra Fragale et al. · Nature Genetics · 2003 · 1K citations

Hematological Malignancy, Chromatin, Somatic Variant +10

The triple origin of skull in higher vertebrates: a study in quail-chick chimeras

G Couly, Pierre Coltey, Nicole M. Le Douarin · Development · 1993 · 1K citations

Crystal Structure of the Tyrosine Phosphatase SHP-2

Peter Hof, Scott Pluskey, Sirano Dhe‐Paganon et al. · Cell · 1998 · 990 citations · Full text

Crystal Structure, Biochemistry, Protein X-ray Crystallography +3