Characteristics of CD59 up‐regulation induced in porcine endothelial cells by αGal ligation and its association with protection from complement

Abstract

Induction of CD59 expression required specific binding of the lectin to terminal alphaGal and was not induced by soluble factors that may be released from EC by lectin stimulation. Increased CD59 expression may contribute to this form of protection from complement; however, mechanisms other than CD59 up-regulation appear to be essential for the development of full protection.