Reversal of rocuronium-induced neuromuscular block by sugammadex is independent of renal perfusion in anesthetized cats

Residual neuromuscular block is a risk factor for postoperative pulmonary complications A prospective, randomised, and blinded study of postoperative pulmonary complications after atracurium, vecuronium and pancuronium

Hans E. Berg, J. Viby‐Mogensen, Jakob Roed et al. · Acta Anaesthesiologica Scandinavica · 1997 · 656 citations

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Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision

Thomas Fuchs‐Buder, Casper Claudius, Lene Theil Skovgaard et al. · Acta Anaesthesiologica Scandinavica · 2007 · 618 citations · Full text

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A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie International Edition · 2002 · 457 citations

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Reversal of Rocuronium-induced Neuromuscular Block by the Selective Relaxant Binding Agent Sugammadex

Iben Foss Sorgenfrei, K. Norrild, Per Larsen et al. · Anesthesiology · 2006 · 341 citations

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First Human Exposure of Org 25969, a Novel Agent to Reverse the Action of Rocuronium Bromide

Francois Gijsenbergh, Steven Ramael, Natalie Houwing et al. · Anesthesiology · 2005 · 310 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15